Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

Bacterial pathogens show high levels of chromosomal genetic diversity, but the influence of this diversity on the evolution of antibiotic resistance by plasmid acquisition remains unclear. Here, we address this problem in the context of colistin, a ‘last line of defence’ antibiotic. Using experiment...

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Detalles Bibliográficos
Autores principales: Jangir, Pramod K, Yang, Qiue, Shaw, Liam P, Caballero, Julio Diaz, Ogunlana, Lois, Wheatley, Rachel, Walsh, Timothy, MacLean, R Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363117/
https://www.ncbi.nlm.nih.gov/pubmed/35943060
http://dx.doi.org/10.7554/eLife.78834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363117/
https://www.ncbi.nlm.nih.gov/pubmed/35943060
http://dx.doi.org/10.7554/eLife.78834

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