Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-mutational alterations. Recent work has shown that the length distribution of cfDNA fragments from a cancer patient can inform tumor load and type. Here, we propose non-negative matr...

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Detalles Bibliográficos
Autores principales: Renaud, Gabriel, Nørgaard, Maibritt, Lindberg, Johan, Grönberg, Henrik, De Laere, Bram, Jensen, Jørgen Bjerggaard, Borre, Michael, Andersen, Claus Lindbjerg, Sørensen, Karina Dalsgaard, Maretty, Lasse, Besenbacher, Søren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363120/
https://www.ncbi.nlm.nih.gov/pubmed/35894300
http://dx.doi.org/10.7554/eLife.71569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363120/
https://www.ncbi.nlm.nih.gov/pubmed/35894300
http://dx.doi.org/10.7554/eLife.71569

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