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Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis

Although clozapine is the most effective pharmacotherapy for treatment-resistant schizophrenia, it is under-utilized, and initiation is often delayed. One reason is the occurrence of a potentially fatal adverse reaction, clozapine-induced agranulocytosis (CIA). Identifying genetic variations contrib...

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Detalles Bibliográficos
Autores principales: Islam, Farhana, Hain, Daniel, Lewis, David, Law, Rebecca, Brown, Lisa C., Tanner, Julie-Anne, Müller, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363274/
https://www.ncbi.nlm.nih.gov/pubmed/35710824
http://dx.doi.org/10.1038/s41397-022-00281-9