Resurrection of sildenafil: potential for Huntington’s Disease, too?

The phosphodiesterase-5 inhibitor sildenafil was postulated to reduce the risk for Alzheimer’s Disease. Since preclinical data revealed beneficial effects in Huntington’s Disease (HD), we now for the first time investigated effects of sildenafil in HD patients using the database ENROLL-HD. We demons...

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Detalles Bibliográficos
Autores principales: Achenbach, Jannis, Faissner, Simon, Saft, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Short Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363275/
https://www.ncbi.nlm.nih.gov/pubmed/35633374
http://dx.doi.org/10.1007/s00415-022-11196-7
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author Achenbach, Jannis
Faissner, Simon
Saft, Carsten
author_facet Achenbach, Jannis
Faissner, Simon
Saft, Carsten
author_sort Achenbach, Jannis
collection PubMed
description The phosphodiesterase-5 inhibitor sildenafil was postulated to reduce the risk for Alzheimer’s Disease. Since preclinical data revealed beneficial effects in Huntington’s Disease (HD), we now for the first time investigated effects of sildenafil in HD patients using the database ENROLL-HD. We demonstrate beneficial effects on motoric, functional and cognitive capacities in cross-sectional data. Those effects were not explained by underlying fundamental molecular genetic or demographic data. It remains unsolved, if effects are due to behavioral differences or due to direct dose-dependent neurobiological modulations.
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spelling pubmed-93632752022-08-11 Resurrection of sildenafil: potential for Huntington’s Disease, too? Achenbach, Jannis Faissner, Simon Saft, Carsten J Neurol Short Commentary The phosphodiesterase-5 inhibitor sildenafil was postulated to reduce the risk for Alzheimer’s Disease. Since preclinical data revealed beneficial effects in Huntington’s Disease (HD), we now for the first time investigated effects of sildenafil in HD patients using the database ENROLL-HD. We demonstrate beneficial effects on motoric, functional and cognitive capacities in cross-sectional data. Those effects were not explained by underlying fundamental molecular genetic or demographic data. It remains unsolved, if effects are due to behavioral differences or due to direct dose-dependent neurobiological modulations. Springer Berlin Heidelberg 2022-05-28 2022 /pmc/articles/PMC9363275/ /pubmed/35633374 http://dx.doi.org/10.1007/s00415-022-11196-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Commentary
Achenbach, Jannis
Faissner, Simon
Saft, Carsten
Resurrection of sildenafil: potential for Huntington’s Disease, too?
title Resurrection of sildenafil: potential for Huntington’s Disease, too?
title_full Resurrection of sildenafil: potential for Huntington’s Disease, too?
title_fullStr Resurrection of sildenafil: potential for Huntington’s Disease, too?
title_full_unstemmed Resurrection of sildenafil: potential for Huntington’s Disease, too?
title_short Resurrection of sildenafil: potential for Huntington’s Disease, too?
title_sort resurrection of sildenafil: potential for huntington’s disease, too?
topic Short Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363275/
https://www.ncbi.nlm.nih.gov/pubmed/35633374
http://dx.doi.org/10.1007/s00415-022-11196-7
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