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Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease

BACKGROUND: Proenkephalin (PENK) and prodynorphin (PDYN) are peptides mainly produced by the striatal medium spiny projection neurons (MSNs) under dopaminergic signaling. Therefore, they may represent candidate biomarkers in Huntington’s disease (HD) and Parkinson’s disease (PD), two neurodegenerati...

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Detalles Bibliográficos
Autores principales: Barschke, Peggy, Abu-Rumeileh, Samir, Al Shweiki, M. H. D. Rami, Barba, Lorenzo, Paolini Paoletti, Federico, Oeckl, Patrick, Steinacker, Petra, Halbgebauer, Steffen, Gaetani, Lorenzo, Lewerenz, Jan, Ludolph, Albert Christian, Landwehrmeyer, Georg Bernhard, Parnetti, Lucilla, Otto, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363351/
https://www.ncbi.nlm.nih.gov/pubmed/35737109
http://dx.doi.org/10.1007/s00415-022-11187-8