Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular regulatory mechanisms remain unfolded. Here, we report that congenital ablation of the microRNA-synthesizing enzyme, Dicer, in Kiss1 cells, causes late-onset hypogonadotropic hypogonadism in both sexes...

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Detalles Bibliográficos
Autores principales: Roa, Juan, Ruiz-Cruz, Miguel, Ruiz-Pino, Francisco, Onieva, Rocio, Vazquez, Maria J., Sanchez-Tapia, Maria J., Ruiz-Rodriguez, Jose M., Sobrino, Veronica, Barroso, Alexia, Heras, Violeta, Velasco, Inmaculada, Perdices-Lopez, Cecilia, Ohlsson, Claes, Avendaño, Maria Soledad, Prevot, Vincent, Poutanen, Matti, Pinilla, Leonor, Gaytan, Francisco, Tena-Sempere, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363423/
https://www.ncbi.nlm.nih.gov/pubmed/35945211
http://dx.doi.org/10.1038/s41467-022-32347-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363423/
https://www.ncbi.nlm.nih.gov/pubmed/35945211
http://dx.doi.org/10.1038/s41467-022-32347-4

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