Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma

Aberrant epigenetic drivers or suppressors contribute to LUAD progression and drug resistance, including KRAS, PTEN, Keap1. Human Plant Homeodomain (PHD) finger protein 1 (PHF1) coordinates with H3K36me3 to increase nucleosomal DNA accessibility. Previous studies revealed that PHF1 is markedly upreg...

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Detalles Bibliográficos
Autores principales: Ning, Jinfeng, Wang, Fengjiao, Bu, Jianlong, Zhu, Kaibin, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363432/
https://www.ncbi.nlm.nih.gov/pubmed/35945194
http://dx.doi.org/10.1038/s41420-022-01125-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363432/
https://www.ncbi.nlm.nih.gov/pubmed/35945194
http://dx.doi.org/10.1038/s41420-022-01125-y

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