Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma

Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored. By focusing and genotyping head and neck squamous cell carcinoma (HNSCC) that had available pathologic and clinical data, we provide evidence...

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Detalles Bibliográficos
Autores principales: Islam, Syed S., Qassem, Khawlah, Islam, Shafiqul, Parag, Rashed R., Rahman, Mohammed Z., Farhat, Walid A., Yeger, Herman, Aboussekhra, Abdelilah, Karakas, Bedri, Noman, Abu Shadat M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363464/
https://www.ncbi.nlm.nih.gov/pubmed/35945195
http://dx.doi.org/10.1038/s41419-022-05126-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363464/
https://www.ncbi.nlm.nih.gov/pubmed/35945195
http://dx.doi.org/10.1038/s41419-022-05126-8

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