Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which encode proteins that negatively regulate mTOR complex 1 (mTORC1) signaling. Current treatment strategies focus on mTOR inhibition with rapamycin and its derivatives. While effective...

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Detalles Bibliográficos
Autores principales: Karalis, Vasiliki, Caval-Holme, Franklin, Bateup, Helen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363483/
https://www.ncbi.nlm.nih.gov/pubmed/35945201
http://dx.doi.org/10.1038/s41467-022-31961-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363483/
https://www.ncbi.nlm.nih.gov/pubmed/35945201
http://dx.doi.org/10.1038/s41467-022-31961-6

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