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Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex
Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which encode proteins that negatively regulate mTOR complex 1 (mTORC1) signaling. Current treatment strategies focus on mTOR inhibition with rapamycin and its derivatives. While effective...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363483/ https://www.ncbi.nlm.nih.gov/pubmed/35945201 http://dx.doi.org/10.1038/s41467-022-31961-6 |