Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts

Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix (ECM) resulting in fibrosis. Fibrotic ECM has altered mechanical and architectural properties, but the feedback onto FAPs...

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Detalles Bibliográficos
Autores principales: Loomis, Taryn, Hu, Lin-Ya, Wohlgemuth, Ross P., Chellakudam, Rosemary R., Muralidharan, Pooja D., Smith, Lucas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363488/
https://www.ncbi.nlm.nih.gov/pubmed/35945422
http://dx.doi.org/10.1038/s41598-022-17852-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363488/
https://www.ncbi.nlm.nih.gov/pubmed/35945422
http://dx.doi.org/10.1038/s41598-022-17852-2

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