PYK2 senses calcium through a disordered dimerization and calmodulin-binding element

Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker between the PYK2 kinase and FAT domains (KFL) enco...

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Detalles Bibliográficos
Autores principales: Momin, Afaque A., Mendes, Tiago, Barthe, Philippe, Faure, Camille, Hong, SeungBeom, Yu, Piao, Kadaré, Gress, Jaremko, Mariusz, Girault, Jean-Antoine, Jaremko, Łukasz, Arold, Stefan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363500/
https://www.ncbi.nlm.nih.gov/pubmed/35945264
http://dx.doi.org/10.1038/s42003-022-03760-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363500/
https://www.ncbi.nlm.nih.gov/pubmed/35945264
http://dx.doi.org/10.1038/s42003-022-03760-8

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