Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress

Alexander disease is a fatal neurological disorder caused by mutations in the intermediate filament protein Glial Fibrillary Acidic Protein (GFAP), which is key for astrocyte homeostasis. These mutations cause GFAP aggregation, astrocyte dysfunction and neurodegeneration. Remarkably, most of the kno...

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Detalles Bibliográficos
Autores principales: Viedma-Poyatos, Álvaro, González-Jiménez, Patricia, Pajares, María A., Pérez-Sala, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364016/
https://www.ncbi.nlm.nih.gov/pubmed/35933901
http://dx.doi.org/10.1016/j.redox.2022.102415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364016/
https://www.ncbi.nlm.nih.gov/pubmed/35933901
http://dx.doi.org/10.1016/j.redox.2022.102415

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