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Chronic hyperinsulinemia promotes human hepatocyte senescence
OBJECTIVE: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-related diseases. Recently, several human and mous...
Autores principales: | Baboota, Ritesh K., Spinelli, Rosa, Erlandsson, Malin C., Brandao, Bruna B., Lino, Marsel, Yang, Hong, Mardinoglu, Adil, Bokarewa, Maria I., Boucher, Jeremie, Kahn, C. Ronald, Smith, Ulf |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364104/ https://www.ncbi.nlm.nih.gov/pubmed/35872305 http://dx.doi.org/10.1016/j.molmet.2022.101558 |
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