Cargando…

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

During spliceosome assembly, the 3′ splice site is recognized by sequential U2AF2 complexes, first with Splicing Factor 1 (SF1) and second by the SF3B1 subunit of the U2 small nuclear ribonuclear protein particle. The U2AF2–SF1 interface is well characterized, comprising a U2AF homology motif (UHM)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galardi, Justin W., Bela, Victoria N., Jeffery, Nazish, He, Xueyang, Glasser, Eliezra, Loerch, Sarah, Jenkins, Jermaine L., Pulvino, Mary J., Boutz, Paul L., Kielkopf, Clara L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364107/ https://www.ncbi.nlm.nih.gov/pubmed/35780835 http://dx.doi.org/10.1016/j.jbc.2022.102224

Ejemplares similares

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction
por: Talkish, Jason, et al.
Publicado: (2019)

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal
por: Glasser, Eliezra, et al.
Publicado: (2022)

Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors
por: Pabis, Marta, et al.
Publicado: (2019)

Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise
por: Loerch, Sarah, et al.
Publicado: (2016)

U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
por: Jenkins, Jermaine L., et al.
Publicado: (2013)

An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal
por: Agrawal, Anant A., et al.
Publicado: (2016)

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation
por: Warnasooriya, Chandani, et al.
Publicado: (2020)

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
por: Jagtap, Pravin Kumar Ankush, et al.
Publicado: (2020)

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival
por: Fei, Dennis Liang, et al.
Publicado: (2016)

Ulm design : the morality of objects = Hochschule für Gestaltung Ulm, 1953-1968 /
Publicado: (1991)

Bond Performance of Sand Coated UHM CFRP Tendons in High Performance Concrete
por: Lämmlein, Tobias Dominik, et al.
Publicado: (2017)

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing
por: Choi, Namjeong, et al.
Publicado: (2020)

U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing
por: Okeyo-Owuor, Theresa, et al.
Publicado: (2014)

Lifestyle changes and prevention of metabolic syndrome in the Heart of New Ulm Project
por: VanWormer, Jeffrey J., et al.
Publicado: (2017)

Accelerometer-based physical activity in a large observational cohort - study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study
por: Denkinger, Michael D, et al.
Publicado: (2010)

Alteration of the SETBP1 Gene and Splicing Pathway Genes SF3B1, U2AF1, and SRSF2 in Childhood Acute Myeloid Leukemia
por: Choi, Hyun-Woo, et al.
Publicado: (2015)

Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF(65)
por: Hastings, Michelle L., et al.
Publicado: (2007)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

RNA structure replaces the need for U2AF2 in splicing
por: Lin, Chien-Ling, et al.
Publicado: (2016)

Program Participation and Blood Pressure Improvement in the Heart of New Ulm Project, Minnesota, 2009–2011
por: Sillah, Arthur, et al.
Publicado: (2014)

RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES
por: Graubert, Timothy A., et al.
Publicado: (2011)

Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation
por: Sha, Fern, et al.
Publicado: (2023)

The SF3b complex: splicing and beyond
por: Sun, Chengfu
Publicado: (2020)

The Ulm Study and the implications for the advisory services of the Dean of Studies at the Medical Faculty of Heidelberg
por: Nützenadel, Susanne, et al.
Publicado: (2012)

Targeting of U2AF(65) to Sites of Active Splicing in the Nucleus
por: Gama-Carvalho, Margarida, et al.
Publicado: (1997)

Seasonal Mesophotic Coral Bleaching of Stylophora pistillata in the Northern Red Sea
por: Nir, Orit, et al.
Publicado: (2014)

Detained introns are a novel, widespread class of post-transcriptionally spliced introns
por: Boutz, Paul L., et al.
Publicado: (2015)

Long-term ventilation of patients with Duchenne muscular dystrophy: experiences at the Neuromuscular Centre Ulm
por: WOLLINSKY, KURT H., et al.
Publicado: (2012)

Screen Time, Physical Activity and Self-Esteem in Children: The Ulm Birth Cohort Study
por: Braig, Stefanie, et al.
Publicado: (2018)

Prediction of BMI at age 11 in a longitudinal sample of the Ulm Birth Cohort Study
por: Christiansen, Hanna, et al.
Publicado: (2017)

Health and Subjective Views on Aging: Longitudinal Findings From the ActiFE Ulm Study
por: Schönstein, Anton, et al.
Publicado: (2021)

50 years of the first ethics commission in Germany: the Ulm Ethics Commission in an international perspective
por: Steger, Florian, et al.
Publicado: (2023)

XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265
por: Mangs, A. Helena, et al.
Publicado: (2006)

A randomized phase II study of letrozole vs. observation in patients with newly diagnosed uterine leiomyosarcoma (uLMS)
por: Slomovitz, Brian M., et al.
Publicado: (2018)

Splice site m(6)A methylation prevents binding of U2AF35 to inhibit RNA splicing
por: Mendel, Mateusz, et al.
Publicado: (2021)

Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study
por: Logan, Chad A., et al.
Publicado: (2018)

Leptin in Human Milk and Child Body Mass Index: Results of the Ulm Birth Cohort Studies
por: Logan, Chad A., et al.
Publicado: (2019)

Population-level changes in lifestyle risk factors for cardiovascular disease in the Heart of New Ulm Project
por: Benson, Gretchen, et al.
Publicado: (2019)

Changes in Human Milk Fatty Acid Composition during Lactation: The Ulm SPATZ Health Study
por: Siziba, Linda P., et al.
Publicado: (2019)

Human Milk Oligosaccharide Profiles over 12 Months of Lactation: The Ulm SPATZ Health Study
por: Siziba, Linda P., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j8h0f8ql3oit7lmfqa87sjo2uc