Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing

Ferroptosis is a form of cell death triggered by phospholipid hydroperoxides (PLOOH) generated from the iron-dependent oxidation of polyunsaturated fatty acids (PUFAs). To prevent ferroptosis, cells rely on the antioxidant glutathione (GSH), which serves as cofactor of the glutathione peroxidase 4 (...

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Detalles Bibliográficos
Autores principales: Pontel, Lucas B., Bueno-Costa, Alberto, Morellato, Agustín E., Carvalho Santos, Juliana, Roué, Gaël, Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364119/
https://www.ncbi.nlm.nih.gov/pubmed/35944469
http://dx.doi.org/10.1016/j.redox.2022.102408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364119/
https://www.ncbi.nlm.nih.gov/pubmed/35944469
http://dx.doi.org/10.1016/j.redox.2022.102408

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