Anti-multiple myeloma potential of resynthesized belinostat derivatives: an experimental study on cytotoxic activity, drug combination, and docking studies

Multiple myeloma is a deadly cancer that is a complex and multifactorial disease. In the present study, 12 belinostat derivatives (four resynthesized and eight new), HDAC inhibitors, were resynthesized via either Knoevenagel condensation, or Wittig reaction, or Heck reaction. Then an evaluation of t...

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Detalles Bibliográficos
Autores principales: Nguyen, Hong Phuong, Tran, Quang De, Nguyen, Cuong Quoc, Hoa, Tran Phuong, Duy Binh, Tran, Nhu Thao, Huynh, Hue, Bui Thi Buu, Tuan, Nguyen Trong, Le Dang, Quang, Quoc Chau Thanh, Nguyen, Van Ky, Nguyen, Pham, Minh Quan, Yang, Su-Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364358/
https://www.ncbi.nlm.nih.gov/pubmed/36043105
http://dx.doi.org/10.1039/d2ra01969h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364358/
https://www.ncbi.nlm.nih.gov/pubmed/36043105
http://dx.doi.org/10.1039/d2ra01969h

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