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Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

Circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population leads to further viral evolution. The new variants that arise during this evolution are more infectious. Our data suggest that newer variants have shifted from utilizing both cathepsin/endosome- and T...

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Detalles Bibliográficos
Autores principales: Frolova, Elena I., Palchevska, Oksana, Lukash, Tetyana, Dominguez, Francisco, Britt, William, Frolov, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364789/
https://www.ncbi.nlm.nih.gov/pubmed/35876526
http://dx.doi.org/10.1128/jvi.00753-22