Cargando…

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation

Elimination of human immunodeficiency virus (HIV) reservoirs is a critical endpoint to eradicate HIV. One therapeutic intervention against latent HIV is “shock and kill.” This strategy is based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) with the consequent k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Macedo, Amanda B., Levinger, Callie, Nguyen, Bryan N., Richard, Jonathan, Gupta, Mamta, Cruz, Conrad Russell Y., Finzi, Andrés, Chiappinelli, Katherine B., Crandall, Keith A., Bosque, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364794/ https://www.ncbi.nlm.nih.gov/pubmed/35867565 http://dx.doi.org/10.1128/jvi.00372-22

Ejemplares similares

The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
por: Copertino, Dennis C., et al.
Publicado: (2023)

NK Cells Accumulate in Infected Tissues and Contribute to Pathogenicity of Ebola Virus in Mice
por: Fausther-Bovendo, H., et al.
Publicado: (2019)

CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques
por: Mavigner, Maud, et al.
Publicado: (2021)

Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation
por: Matundan, Harry H., et al.
Publicado: (2021)

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway
por: Chen, Da-Yuan, et al.
Publicado: (2021)

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
por: Ruiz-Riol, M., et al.
Publicado: (2017)

Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology
por: Teo, Teck-Hui, et al.
Publicado: (2015)

STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist
por: Le-Trilling, Vu Thuy Khanh, et al.
Publicado: (2018)

Impact of Early ARV Initiation on Relative Proportions of Effector and Regulatory CD8 T Cell in Mesenteric Lymph Nodes and Peripheral Blood During Acute SIV Infection of Rhesus Macaques
por: Yero, Alexis, et al.
Publicado: (2022)

Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model
por: Jeong, Gi Uk, et al.
Publicado: (2023)

Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques
por: McBrien, Julia B., et al.
Publicado: (2020)

Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin
por: Temerozo, Jairo R., et al.
Publicado: (2023)

Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection
por: Harker, James A., et al.
Publicado: (2018)

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels
por: Priceputu, Elena, et al.
Publicado: (2021)

SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1
por: Brown, James R., et al.
Publicado: (2016)

Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs
por: Houzet, Laurent, et al.
Publicado: (2018)

Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes
por: Umviligihozo, Gisele, et al.
Publicado: (2020)

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
por: Chan, Mable, et al.
Publicado: (2022)

Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection
por: Chen, Jennifer S., et al.
Publicado: (2021)

Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
por: Maglennon, G. A., et al.
Publicado: (2014)

Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation
por: Woodburn, Blaide M., et al.
Publicado: (2022)

HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1
por: Sandstrom, Teslin S., et al.
Publicado: (2021)

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice
por: Winkler, Emma S., et al.
Publicado: (2022)

Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection
por: Jiang, Rosie T., et al.
Publicado: (2017)

Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4(+) T Cell Responses
por: Kim, Eun-Ha, et al.
Publicado: (2022)

Intestinal Tropism of a Betacoronavirus (Merbecovirus) in Nathusius’s Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host
por: Mols, Vera C., et al.
Publicado: (2023)

Asymptomatic Primary Infection with Epstein-Barr Virus: Observations on Young Adult Cases
por: Abbott, Rachel J., et al.
Publicado: (2017)

Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice
por: Silvas, Jesus A., et al.
Publicado: (2021)

Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C
por: Tartaglia, Lawrence J., et al.
Publicado: (2020)

Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection
por: Evangelous, Tyler D., et al.
Publicado: (2023)

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants
por: Moyo-Gwete, Thandeka, et al.
Publicado: (2022)

The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus
por: Dong, Wenjuan, et al.
Publicado: (2022)

Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice
por: Wong, Ting Y., et al.
Publicado: (2022)

HLA-B*14:02-Restricted Env-Specific CD8(+) T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection
por: Leitman, Ellen M., et al.
Publicado: (2017)

Identification of Common CD8(+) T Cell Epitopes from Lassa Fever Survivors in Nigeria and Sierra Leone
por: Sakabe, Saori, et al.
Publicado: (2020)

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
por: Ayllon, Juan, et al.
Publicado: (2014)

Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados
por: Juarez-Molina, Claudia I., et al.
Publicado: (2014)

Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection
por: Caporale, Marco, et al.
Publicado: (2014)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_i0jtr5q0imumf8svbf2tafot6j