Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin

Somatic mutations in cancer genomes are associated with DNA replication timing (RT) and chromatin accessibility (CA), however these observations are based on normal tissues and cell lines while primary cancer epigenomes remain uncharacterised. Here we use machine learning to model megabase-scale mut...

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Detalles Bibliográficos
Autores principales: Ocsenas, Oliver, Reimand, Jüri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365152/
https://www.ncbi.nlm.nih.gov/pubmed/35947558
http://dx.doi.org/10.1371/journal.pcbi.1010393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365152/
https://www.ncbi.nlm.nih.gov/pubmed/35947558
http://dx.doi.org/10.1371/journal.pcbi.1010393

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