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Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin
Somatic mutations in cancer genomes are associated with DNA replication timing (RT) and chromatin accessibility (CA), however these observations are based on normal tissues and cell lines while primary cancer epigenomes remain uncharacterised. Here we use machine learning to model megabase-scale mut...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365152/ https://www.ncbi.nlm.nih.gov/pubmed/35947558 http://dx.doi.org/10.1371/journal.pcbi.1010393 |