Cargando…

Amlodipine Improves Spinal Cord Injury Repair by Inhibiting Motoneuronal Apoptosis Through Autophagy Upregulation

The effect of amlodipine (AM) on spinal cord injury (SCI) and autophagy was researched by establishing ventral spinal cord cells (VSC4.1) oxygen and glucose deprivation model and SCI mice model. OBJECTIVE. To determine the neuroprotective effects of AM by upregulating autophagy during SCI repair. SU...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yang, Ren, Hao, Gao, Xiang, Cai, Danyang, Shan, Huajian, Bai, Jinyu, Sheng, Lei, Jin, Yong, Zhou, Xiaozhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365253/ https://www.ncbi.nlm.nih.gov/pubmed/34923548 http://dx.doi.org/10.1097/BRS.0000000000004310

Ejemplares similares

Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro
por: Garcera, A, et al.
Publicado: (2013)

Enrichment of spinal cord cell cultures with motoneurons
Publicado: (1978)

Feedback regulation of locomotion by motoneurons in the vertebrate spinal cord
por: Falgairolle, Melanie, et al.
Publicado: (2019)

Motoneuronal Spinal Circuits in Degenerative Motoneuron Disease
por: Falgairolle, Mélanie, et al.
Publicado: (2020)

Electrophysiology of the Fetal Spinal Cord : I. Action potentials of the motoneuron
por: Naka, Ken-Ichi
Publicado: (1964)

Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury
por: Sengelaub, Dale R., et al.
Publicado: (2018)

Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease
por: Gulino, Rosario
Publicado: (2016)

Paired corticospinal-motoneuronal stimulation and exercise after spinal cord injury
por: Jo, Hang Jin, et al.
Publicado: (2021)

Nkx2.2+ Progenitors Generate Somatic Motoneurons in the Chick Spinal Cord
por: Gotoh, Hitoshi, et al.
Publicado: (2012)

Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease
por: Gulino, Rosario, et al.
Publicado: (2015)

Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS
por: Ouali Alami, Najwa, et al.
Publicado: (2020)

Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity
por: Plantier, Vanessa, et al.
Publicado: (2019)

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord
por: Greiner, Nathan, et al.
Publicado: (2021)

Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition
por: Pan, Xuekang, et al.
Publicado: (2022)

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair
por: Fan, Qin, et al.
Publicado: (2021)

Modeling morphological changes in spinal motoneurons following spinal cord injury to explore changes in electrical behavior
por: Graham, Joe W, et al.
Publicado: (2007)

Noradrenergic Modulation of Intrinsic and Synaptic Properties of Lumbar Motoneurons in the Neonatal Rat Spinal Cord
por: Tartas, Maylis, et al.
Publicado: (2010)

Transspinal stimulation increases motoneuron output of multiple segments in human spinal cord injury
por: Murray, Lynda M., et al.
Publicado: (2019)

Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones
por: Irvine, Sian F., et al.
Publicado: (2018)

Inflammation & apoptosis in spinal cord injury
por: Zhang, Ning, et al.
Publicado: (2012)

Early electrical field stimulation prevents the loss of spinal cord anterior horn motoneurons and muscle atrophy following spinal cord injury
por: Zhang, Cheng, et al.
Publicado: (2018)

Gain control mechanisms in spinal motoneurons
por: Johnson, Michael D., et al.
Publicado: (2014)

Identification of the Avulsion-Injured Spinal Motoneurons
por: Tan, Min, et al.
Publicado: (2015)

Factors influencing the spinal motoneurons in development
por: Wiese, Stefan
Publicado: (2015)

Activity-dependent plasticity in desecending synaptic inputs to spinal motoneurons in an in vitro turtle brainstem-spinal cord preparation
por: Johnson, SM, et al.
Publicado: (2001)

Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
por: de la Fuente, Sandra, et al.
Publicado: (2018)

The Effect of Distal Aortic Pressure on Spinal Cord Perfusion in Rats
por: Park, Sung-Min, et al.
Publicado: (2012)

Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury
por: Nazli, Yunus, et al.
Publicado: (2015)

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
por: Cristofani, Riccardo, et al.
Publicado: (2017)

Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons
por: Sansa, Alba, et al.
Publicado: (2021)

Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation
por: Lee, Sungyoub, et al.
Publicado: (2012)

The Use of PRV-Bartha to Define Premotor Inputs to Lumbar Motoneurons in the Neonatal Spinal Cord of the Mouse
por: Jovanovic, Ksenija, et al.
Publicado: (2010)

Epidural and transcutaneous spinal cord stimulation facilitates descending inputs to upper-limb motoneurons in monkeys
por: Guiho, Thomas, et al.
Publicado: (2021)

Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection
por: Takiguchi, Masahito, et al.
Publicado: (2022)

AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury
por: Michel-Flutot, Pauline, et al.
Publicado: (2022)

Lower Motoneuron Dysfunction Impacts Spontaneous Motor Recovery in Acute Cervical Spinal Cord Injury
por: Franz, Steffen, et al.
Publicado: (2023)

Neuroprotective effect of epidural hypothermia after spinal cord lesion in rats
por: Barbosa, Marcello Oliveira, et al.
Publicado: (2014)

Expression of Hyaluronidase-4 in a Rat Spinal Cord Hemisection Model
por: Tachi, Yoshiyuki, et al.
Publicado: (2015)

Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats
por: Sivanesan, Eellan, et al.
Publicado: (2019)

INFLUENCE OF ASPHYXIA UPON THE RESPONSES OF SPINAL MOTONEURONS
por: Lloyd, David P. C.
Publicado: (1953)

Cannot write session to /tmp/vufind_sessions/sess_bs692c0b4p3opmh99al7bfs1mu