Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry

Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification by fourfold compared to reported methods and reve...

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Detalles Bibliográficos
Autores principales: Su, Pei, McGee, John P., Durbin, Kenneth R., Hollas, Michael A. R., Yang, Manxi, Neumann, Elizabeth K., Allen, Jamie L., Drown, Bryon S., Butun, Fatma Ayaloglu, Greer, Joseph B., Early, Bryan P., Fellers, Ryan T., Spraggins, Jeffrey M., Laskin, Julia, Camarillo, Jeannie M., Kafader, Jared O., Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365283/
https://www.ncbi.nlm.nih.gov/pubmed/35947651
http://dx.doi.org/10.1126/sciadv.abp9929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365283/
https://www.ncbi.nlm.nih.gov/pubmed/35947651
http://dx.doi.org/10.1126/sciadv.abp9929

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