DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

PURPOSE: Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are enriched for tumor stem cells. Here, we tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/...

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Detalles Bibliográficos
Autores principales: Kurani, Hetakshi, Razavipour, Seyedeh Fatemeh, Harikumar, Kuzhuvelil B., Dunworth, Matthew, Ewald, Andrew J., Nasir, Apsra, Pearson, Gray, Van Booven, Derek, Zhou, Zhiqun, Azzam, Diana, Wahlestedt, Claes, Slingerland, Joyce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365344/
https://www.ncbi.nlm.nih.gov/pubmed/35135840
http://dx.doi.org/10.1158/1078-0432.CCR-21-1299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365344/
https://www.ncbi.nlm.nih.gov/pubmed/35135840
http://dx.doi.org/10.1158/1078-0432.CCR-21-1299

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