Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

Small-cell lung cancer (SCLC) is a recalcitrant cancer characterized by high metastasis. However, the exact cell type contributing to metastasis remains elusive. Using a Rb1(L/L)/Trp53(L/L) mouse model, we identify the NCAM(hi)CD44(lo/–) subpopulation as the SCLC metastasizing cell (SMC), which is p...

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Detalles Bibliográficos
Autores principales: Jin, Yujuan, Zhao, Qiqi, Zhu, Weikang, Feng, Yan, Xiao, Tian, Zhang, Peng, Jiang, Liyan, Hou, Yingyong, Guo, Chenchen, Huang, Hsinyi, Chen, Yabin, Tong, Xinyuan, Cao, Jiayu, Li, Fei, Zhu, Xueliang, Qin, Jun, Gao, Dong, Liu, Xin-Yuan, Zhang, Hua, Chen, Luonan, Thomas, Roman K, Wong, Kwok-Kin, Zhang, Lei, Wang, Yong, Hu, Liang, Ji, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365451/
https://www.ncbi.nlm.nih.gov/pubmed/35967587
http://dx.doi.org/10.1093/nsr/nwab232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365451/
https://www.ncbi.nlm.nih.gov/pubmed/35967587
http://dx.doi.org/10.1093/nsr/nwab232

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