Structural plasticity in I-A(g7) links autoreactivity to hybrid insulin peptides in type I diabetes

We recently provided evidence for promiscuous recognition of several different hybrid insulin peptides (HIPs) by the highly diabetogenic, I-A(g7)-restricted 4.1-T cell receptor (TCR). To understand the structural determinants of this phenomenon, we solved the structure of an agonistic HIP/I-A(g7) co...

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Detalles Bibliográficos
Autores principales: Erausquin, Elena, Serra, Pau, Parras, Daniel, Santamaria, Pere, López-Sagaseta, Jacinto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365947/
https://www.ncbi.nlm.nih.gov/pubmed/35967292
http://dx.doi.org/10.3389/fimmu.2022.924311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365947/
https://www.ncbi.nlm.nih.gov/pubmed/35967292
http://dx.doi.org/10.3389/fimmu.2022.924311

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