Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function

ARF tumor suppressor protein is a key regulator of the MDM2-p53 signaling axis. ARF interferes with MDM2-mediated ubiquitination and degradation of p53 by sequestering MDM2 in the nucleolus and preventing MDM2-p53 interaction and nuclear export of p53. Moreover, ARF also directly inhibits MDM2 ubiqu...

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Detalles Bibliográficos
Autores principales: Kowalczyk, Dominika, Nakasone, Mark A, Smith, Brian O, Huang, Danny T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366199/
https://www.ncbi.nlm.nih.gov/pubmed/35944929
http://dx.doi.org/10.26508/lsa.202201472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366199/
https://www.ncbi.nlm.nih.gov/pubmed/35944929
http://dx.doi.org/10.26508/lsa.202201472

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