Cargando…

Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function

ARF tumor suppressor protein is a key regulator of the MDM2-p53 signaling axis. ARF interferes with MDM2-mediated ubiquitination and degradation of p53 by sequestering MDM2 in the nucleolus and preventing MDM2-p53 interaction and nuclear export of p53. Moreover, ARF also directly inhibits MDM2 ubiqu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kowalczyk, Dominika, Nakasone, Mark A, Smith, Brian O, Huang, Danny T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366199/ https://www.ncbi.nlm.nih.gov/pubmed/35944929 http://dx.doi.org/10.26508/lsa.202201472

Ejemplares similares

Deconstructing nucleotide binding activity of the Mdm2 RING domain
por: Priest, Christina, et al.
Publicado: (2010)

MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells
por: Vivo, Maria, et al.
Publicado: (2015)

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
por: Gabrielsen, Mads, et al.
Publicado: (2017)

Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets
por: Bulatov, Emil, et al.
Publicado: (2018)

Genetic Variation in MDM2 and p14 (ARF) and Susceptibility to Salivary Gland Carcinoma
por: Jin, Lei, et al.
Publicado: (2012)

Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain
por: Ilic, Viktoria K., et al.
Publicado: (2022)

Tau protein binds to the P53 E3 ubiquitin ligase MDM2
por: Sola, Martina, et al.
Publicado: (2023)

Pinning Control for the p53-Mdm2 Network Dynamics Regulated by p14ARF
por: Suarez, Oscar J., et al.
Publicado: (2020)

Zinc Binding Properties of Engineered RING Finger Domain of Arkadia E3 Ubiquitin Ligase
por: Chasapis, Christos T., et al.
Publicado: (2010)

Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant
por: Magnussen, Helge M., et al.
Publicado: (2021)

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF
por: Lo, Dorothy, et al.
Publicado: (2014)

MDM2-C Functions as an E3 Ubiquitin Ligase
por: Kim, Jun Yeob, et al.
Publicado: (2020)

Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells
por: Egorova, Olga, et al.
Publicado: (2020)

Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators
por: Schlott, T, et al.
Publicado: (2002)

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
por: Coffill, Cynthia R., et al.
Publicado: (2016)

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
por: Magnussen, Helge M., et al.
Publicado: (2020)

Overexpression of CCDC69 activates p14(ARF)/MDM2/p53 pathway and confers cisplatin sensitivity
por: Cui, Long, et al.
Publicado: (2019)

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases
por: Chatrin, Chatrin, et al.
Publicado: (2020)

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells
por: Wade, Mark, et al.
Publicado: (2012)

MDM2 is a novel E3 ligase for HIV-1 Vif
por: Izumi, Taisuke, et al.
Publicado: (2009)

hCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex
por: Huang, Xinping, et al.
Publicado: (2023)

Targeting RING domains of Mdm2–MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells
por: Wu, W, et al.
Publicado: (2015)

GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin
por: Yun, Yaejin, et al.
Publicado: (2023)

LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2017)

Structural modeling of protein ensembles between E3 RING ligases and SARS-CoV-2: The role of zinc binding domains
por: Chasapis, Christos T., et al.
Publicado: (2023)

Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases
por: Devkota, Sushil, et al.
Publicado: (2016)

MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity
por: He, Ying, et al.
Publicado: (2013)

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
por: Kwon, Duk-Hwa, et al.
Publicado: (2016)

Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
por: Kwon, Duk-Hwa, et al.
Publicado: (2021)

Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2018)

Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair
por: Zhang, Fan, et al.
Publicado: (2014)

Mdm2 enhances ligase activity of parkin and facilitates mitophagy
por: Kook, Seunghyi, et al.
Publicado: (2020)

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity
por: Liu, Jinyi, et al.
Publicado: (2012)

Decreased Mdm2 Expression Inhibits Tumor Development and Extends Survival Independent of Arf and Dependent on p53
por: Eischen, Christine M., et al.
Publicado: (2012)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
por: Maniaci, Chiara, et al.
Publicado: (2017)

Decoding the Role of MDM2 as a Potential Ubiquitin E3 Ligase and Identifying the Therapeutic Efficiency of Alkaloids against MDM2 in Combating Glioblastoma
por: Sharma, Sudhanshu, et al.
Publicado: (2023)

Synthetic (10)FN3-based mono- and bivalent inhibitors of MDM2/X function
por: Lau, S -Y, et al.
Publicado: (2018)

Aberrant Expression of pRb, p16, p14ARF, MDM2, p21 and p53 in Squamous Cell Carcinomas of Lung
por: Xue, Qi, et al.
Publicado: (2001)

The Anti-Proliferative Effects of the CHFR Depend on the Forkhead Associated Domain, but not E3 Ligase Activity Mediated by Ring Finger Domain
por: Fukuda, Tomokazu, et al.
Publicado: (2008)

ZFP14 Regulates Cancer Cell Growth and Migration by Modulating p53 Protein Stability as Part of the MDM2 E3 Ubiquitin Ligase Complex
por: Mohibi, Shakur, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1oovh7g9bir317mkb9tpbhnihl