Towards novel tacrine analogues: Pd(dppf)Cl(2)·CH(2)Cl(2) catalyzed improved synthesis, in silico docking and hepatotoxicity studies

A plethora of 6-(hetero)aryl C–C and C–N bonded tacrine analogues has been made accessible by employing palladium mediated (Suzuki–Miyaura, Heck, Sonogashira, Stille and Buchwald) cross-coupling reactions, starting from either halogenated or borylated residues. The successful use of Pd(dppf)Cl(2)·CH...

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Detalles Bibliográficos
Autores principales: Babu, Aravinda, Joy, Muthipeedika Nibin, Sunil, K., Sajith, Ayyiliath Meleveetil, Santra, Sougata, Zyryanov, Grigory V., Konovalova, Olga A., Butorin, Ilya I., Muniraju, Keesaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366599/
https://www.ncbi.nlm.nih.gov/pubmed/36105950
http://dx.doi.org/10.1039/d2ra03225b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366599/
https://www.ncbi.nlm.nih.gov/pubmed/36105950
http://dx.doi.org/10.1039/d2ra03225b

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