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Towards novel tacrine analogues: Pd(dppf)Cl(2)·CH(2)Cl(2) catalyzed improved synthesis, in silico docking and hepatotoxicity studies
A plethora of 6-(hetero)aryl C–C and C–N bonded tacrine analogues has been made accessible by employing palladium mediated (Suzuki–Miyaura, Heck, Sonogashira, Stille and Buchwald) cross-coupling reactions, starting from either halogenated or borylated residues. The successful use of Pd(dppf)Cl(2)·CH...
Autores principales: | Babu, Aravinda, Joy, Muthipeedika Nibin, Sunil, K., Sajith, Ayyiliath Meleveetil, Santra, Sougata, Zyryanov, Grigory V., Konovalova, Olga A., Butorin, Ilya I., Muniraju, Keesaram |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366599/ https://www.ncbi.nlm.nih.gov/pubmed/36105950 http://dx.doi.org/10.1039/d2ra03225b |
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