Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to suppo...

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Detalles Bibliográficos
Autores principales: Srinivasan, Vasundara, Brognaro, Hévila, Prabhu, Prince R., de Souza, Edmarcia Elisa, Günther, Sebastian, Reinke, Patrick Y. A., Lane, Thomas J., Ginn, Helen, Han, Huijong, Ewert, Wiebke, Sprenger, Janina, Koua, Faisal H. M., Falke, Sven, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Franca, Bruno Alves, Wang, Mengying, Barra, Angélica Luana C., Perbandt, Markus, Schwinzer, Martin, Schmidt, Christina, Brings, Lea, Lorenzen, Kristina, Schubert, Robin, Machado, Rafael Rahal Guaragna, Candido, Erika Donizette, Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Niebling, Stephan, Garcia, Angelica Struve, Yefanov, Oleksandr, Lieske, Julia, Gelisio, Luca, Domaracky, Martin, Middendorf, Philipp, Groessler, Michael, Trost, Fabian, Galchenkova, Marina, Mashhour, Aida Rahmani, Saouane, Sofiane, Hakanpää, Johanna, Wolf, Markus, Alai, Maria Garcia, Turk, Dusan, Pearson, Arwen R., Chapman, Henry N., Hinrichs, Winfried, Wrenger, Carsten, Meents, Alke, Betzel, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366811/
https://www.ncbi.nlm.nih.gov/pubmed/35953531
http://dx.doi.org/10.1038/s42003-022-03737-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366811/
https://www.ncbi.nlm.nih.gov/pubmed/35953531
http://dx.doi.org/10.1038/s42003-022-03737-7

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