Practical and Highly Efficient Synthesis of Remdesivir from GS-441524

[Image: see text] A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing N,N-dimethylformamide dimethyl acetal (DMF-DMA) as a protecting agent, this synthesis started from (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(...

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Detalles Bibliográficos
Autores principales: Hu, Tianwen, Zhu, Fuqiang, Xiang, Li, Shen, Jingshan, Xie, Yuanchao, Aisa, Haji A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366944/
https://www.ncbi.nlm.nih.gov/pubmed/35967033
http://dx.doi.org/10.1021/acsomega.2c02835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366944/
https://www.ncbi.nlm.nih.gov/pubmed/35967033
http://dx.doi.org/10.1021/acsomega.2c02835

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