Characterizing Receptor Flexibility to Predict Mutations That Lead to Human Adaptation of Influenza Hemagglutinin

[Image: see text] A key step in the emergence of human pandemic influenza strains has been a switch in binding preference of the viral glycoprotein hemagglutinin (HA) from avian to human sialic acid (SA) receptors. The conformation of the bound SA varies substantially with HA sequence, and crystallo...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Huafeng, Palpant, Timothy, Weinberger, Cody, Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367001/
https://www.ncbi.nlm.nih.gov/pubmed/35815857
http://dx.doi.org/10.1021/acs.jctc.1c01044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367001/
https://www.ncbi.nlm.nih.gov/pubmed/35815857
http://dx.doi.org/10.1021/acs.jctc.1c01044

Ejemplares similares