Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and prevent viral neutralization. Here, we used a directed...

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Detalles Bibliográficos
Autores principales: Zhao, Fangzhu, Keating, Celina, Ozorowski, Gabriel, Shaabani, Namir, Francino-Urdaniz, Irene M., Barman, Shawn, Limbo, Oliver, Burns, Alison, Zhou, Panpan, Ricciardi, Michael J., Woehl, Jordan, Tran, Quoc, Turner, Hannah L., Peng, Linghang, Huang, Deli, Nemazee, David, Andrabi, Raiees, Sok, Devin, Teijaro, John R., Whitehead, Timothy A., Ward, Andrew B., Burton, Dennis R., Jardine, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367177/
https://www.ncbi.nlm.nih.gov/pubmed/35971553
http://dx.doi.org/10.1016/j.isci.2022.104914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367177/
https://www.ncbi.nlm.nih.gov/pubmed/35971553
http://dx.doi.org/10.1016/j.isci.2022.104914

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