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Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides

The oxime ligation is a valuable bioorthogonal conjugation reaction but with limited compatibility with disulfide-rich peptides/proteins and time-sensitive applications. Here we overcome these limitations by introducing a strategy that supports regiospecific control, oxidative folding, production of...

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Detalles Bibliográficos
Autores principales: Hering, Anke, Braga Emidio, Nayara, Muttenthaler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367247/
https://www.ncbi.nlm.nih.gov/pubmed/35880482
http://dx.doi.org/10.1039/d2cc03752a