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Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides
The oxime ligation is a valuable bioorthogonal conjugation reaction but with limited compatibility with disulfide-rich peptides/proteins and time-sensitive applications. Here we overcome these limitations by introducing a strategy that supports regiospecific control, oxidative folding, production of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367247/ https://www.ncbi.nlm.nih.gov/pubmed/35880482 http://dx.doi.org/10.1039/d2cc03752a |