Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling

Bile salts accumulating during cholestatic liver disease are believed to promote liver fibrosis. We have recently shown that chenodeoxycholate (CDC) induces expansion of hepatic stellate cells (HSCs) in vivo, thereby promoting liver fibrosis. Mechanisms underlying bile salt-induced fibrogenesis rema...

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Detalles Bibliográficos
Autores principales: Zimny, Sebastian, Koob, Dennis, Li, Jingguo, Wimmer, Ralf, Schiergens, Tobias, Nagel, Jutta, Reiter, Florian Paul, Denk, Gerald, Hohenester, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367387/
https://www.ncbi.nlm.nih.gov/pubmed/35954188
http://dx.doi.org/10.3390/cells11152344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367387/
https://www.ncbi.nlm.nih.gov/pubmed/35954188
http://dx.doi.org/10.3390/cells11152344

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