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Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling
Bile salts accumulating during cholestatic liver disease are believed to promote liver fibrosis. We have recently shown that chenodeoxycholate (CDC) induces expansion of hepatic stellate cells (HSCs) in vivo, thereby promoting liver fibrosis. Mechanisms underlying bile salt-induced fibrogenesis rema...
Autores principales: | Zimny, Sebastian, Koob, Dennis, Li, Jingguo, Wimmer, Ralf, Schiergens, Tobias, Nagel, Jutta, Reiter, Florian Paul, Denk, Gerald, Hohenester, Simon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367387/ https://www.ncbi.nlm.nih.gov/pubmed/35954188 http://dx.doi.org/10.3390/cells11152344 |
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