Li–Fraumeni Syndrome: Mutation of TP53 Is a Biomarker of Hereditary Predisposition to Tumor: New Insights and Advances in the Treatment

SIMPLE SUMMARY: Li–Fraumeni Syndrome (LFS) is a rare tumor predisposition syndrome in which the tumor suppressor TP53 gene is mutated in the germ cell population. LFS patients develop a broad spectrum of cancers in their lifetime. The risk to develop these tumors is not decreased by any type of trea...

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Detalles Bibliográficos
Autores principales: Rocca, Valentina, Blandino, Giovanni, D’Antona, Lucia, Iuliano, Rodolfo, Di Agostino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367397/
https://www.ncbi.nlm.nih.gov/pubmed/35954327
http://dx.doi.org/10.3390/cancers14153664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367397/
https://www.ncbi.nlm.nih.gov/pubmed/35954327
http://dx.doi.org/10.3390/cancers14153664

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