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Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia

CONTEXT: Paclitaxel (PTX) leads to chemotherapy brain (chemo-brain) which is characterised by cognitive impairment. It has been reported that necroptosis is associated with cognitive impairment in some neurodegenerative diseases, but it is not clear whether it is related to the development of chemo-...

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Detalles Bibliográficos
Autores principales: Tang, Miao, Zhao, Shuang, Liu, Jia-Xin, Liu, Xin, Guo, Yue-Xian, Wang, Gui-Ying, Wang, Xiu-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367659/
https://www.ncbi.nlm.nih.gov/pubmed/35944285
http://dx.doi.org/10.1080/13880209.2022.2108064