Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation

Post-translational modifications can lead to a break in immune tolerance in autoimmune diseases such as type 1 diabetes (T1D). Deamidation, the conversion of glutamine to glutamic acid by transglutaminase (TGM) enzymes, is a post-translational modification of interest, with deamidated peptides being...

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Detalles Bibliográficos
Autores principales: Callebaut, Aїsha, Bruggeman, Ylke, Zamit, Cloé, Sodré, Fernanda Marques Câmara, Irla, Magali, Mathieu, Chantal, Buitinga, Mijke, Overbergh, Lut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367685/
https://www.ncbi.nlm.nih.gov/pubmed/35966081
http://dx.doi.org/10.3389/fendo.2022.908248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367685/
https://www.ncbi.nlm.nih.gov/pubmed/35966081
http://dx.doi.org/10.3389/fendo.2022.908248

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