WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro

Hearing loss affects over 460 million people worldwide and is a major socioeconomic burden. Both genetic and environmental factors (i.e., noise overexposure, ototoxic drug treatment and ageing), promote the irreversible degeneration of cochlear hair cells and associated auditory neurons, leading to...

Descripción completa

Detalles Bibliográficos
Autores principales: Rousset, Francis, Schilardi, Giulia, Sgroi, Stéphanie, Nacher-Soler, German, Sipione, Rebecca, Kleinlogel, Sonja, Senn, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367963/
https://www.ncbi.nlm.nih.gov/pubmed/35954276
http://dx.doi.org/10.3390/cells11152431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367963/
https://www.ncbi.nlm.nih.gov/pubmed/35954276
http://dx.doi.org/10.3390/cells11152431

Ejemplares similares