Cargando…

Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account

Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of recombinant TPCs expressed in enlarged lysosomes in mammalian cells or va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Sandip, Yuan, Yu, Chen, Cheng-Chang, Jaślan, Dawid, Gunaratne, Gihan, Grimm, Christian, Rahman, Taufiq, Marchant, Jonathan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368155/ https://www.ncbi.nlm.nih.gov/pubmed/35954212 http://dx.doi.org/10.3390/cells11152368

Ejemplares similares

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function
por: Grimm, Christian, et al.
Publicado: (2017)

NAADP-dependent Ca(2+) signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system
por: Gunaratne, Gihan S., et al.
Publicado: (2018)

Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed
por: Patel, Sandip, et al.
Publicado: (2016)

Isolated pores dissected from human two-pore channel 2 are functional
por: Penny, Christopher J., et al.
Publicado: (2016)

TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
por: Clement, Dennis, et al.
Publicado: (2020)

Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
por: Abrahamian, Carla, et al.
Publicado: (2021)

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A
por: Fernández, Belén, et al.
Publicado: (2016)

Endolysosomal Cation Channels and Lung Disease
por: Spix, Barbara, et al.
Publicado: (2022)

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers()
por: Penny, Christopher J., et al.
Publicado: (2019)

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation
por: Khan, Nabab, et al.
Publicado: (2020)

Two-pore channels and disease()
por: Patel, Sandip, et al.
Publicado: (2018)

Endolysosomal Cation Channels and Cancer—A Link with Great Potential
por: Grimm, Christian, et al.
Publicado: (2018)

Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers
por: Gunaratne, Gihan S., et al.
Publicado: (2018)

Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019
por: Moccia, Francesco, et al.
Publicado: (2021)

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles
por: Chen, Cheng-Chang, et al.
Publicado: (2020)

Endolysosomal Ca(2+) Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!
por: Faris, Pawan, et al.
Publicado: (2018)

Corrigendum: Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019
por: Moccia, Francesco, et al.
Publicado: (2021)

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals
por: Brailoiu, Eugen, et al.
Publicado: (2010)

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii
por: Li, Zhu-Hong, et al.
Publicado: (2021)

The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection
por: D’Amore, Antonella, et al.
Publicado: (2021)

Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology
por: Lee, Claire Shuk-Kwan, et al.
Publicado: (2016)

Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels
por: Lu, Jinping, et al.
Publicado: (2023)

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
por: Brailoiu, Eugen, et al.
Publicado: (2009)

Animal secretory endolysosome channel discovery
por: Zhang, Yun, et al.
Publicado: (2021)

Domain assembly of NAADP-gated two-pore channels
por: Churamani, Dev, et al.
Publicado: (2011)

Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB
por: Fernández, Belén, et al.
Publicado: (2022)

Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum
por: Gunaratne, Gihan S., et al.
Publicado: (2023)

The protein interaction networks of mucolipins and two-pore channels
por: Krogsaeter, Einar K., et al.
Publicado: (2019)

Two-pore channels as master regulators of membrane trafficking and endocytic well-being
por: Vassileva, Kristin, et al.
Publicado: (2020)

Evolutionary Aspects of TRPMLs and TPCs
por: Jaślan, Dawid, et al.
Publicado: (2020)

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
por: Chen, Qingfeng, et al.
Publicado: (2017)

Deciphering the Role of Endolysosomal Ca(2+) Channels in Immunity
por: Alharbi, Abeer F., et al.
Publicado: (2021)

Segregated cation flux by TPC2 biases Ca(2+) signaling through lysosomes
por: Yuan, Yu, et al.
Publicado: (2022)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells
por: Arredouani, Abdelilah, et al.
Publicado: (2015)

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
por: Hooper, Robert, et al.
Publicado: (2011)

Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation
por: Guo, Xiao-Long, et al.
Publicado: (2019)

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel
por: Park, Sang-Kyu, et al.
Publicado: (2019)

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia
por: Toupenet Marchesi, Liriopé, et al.
Publicado: (2021)

Endolysosomal TRPMLs in Cancer
por: Xu, Mengnan, et al.
Publicado: (2021)

Targeting Two-Pore Channels: Current Progress and Future Challenges
por: Jin, Xuhui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ksjjcmrbfc8tdqf5ocfhs77b3p