The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved

Metformin, a drug widely used in type 2 diabetes (T2D), has been shown to protect human β-cells exposed to gluco- and/or lipotoxic conditions and those in islets from T2D donors. We assessed whether metformin could relieve the human β-cell stress induced by pro-inflammatory cytokines (which mediate...

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Detalles Bibliográficos
Autores principales: Giusti, Laura, Tesi, Marta, Ciregia, Federica, Marselli, Lorella, Zallocco, Lorenzo, Suleiman, Mara, De Luca, Carmela, Del Guerra, Silvia, Zuccarini, Mariachiara, Trerotola, Marco, Eizirik, Decio L., Cnop, Miriam, Mazzoni, Maria R., Marchetti, Piero, Lucacchini, Antonio, Ronci, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368307/
https://www.ncbi.nlm.nih.gov/pubmed/35954309
http://dx.doi.org/10.3390/cells11152465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368307/
https://www.ncbi.nlm.nih.gov/pubmed/35954309
http://dx.doi.org/10.3390/cells11152465

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