Cargando…

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved

Metformin, a drug widely used in type 2 diabetes (T2D), has been shown to protect human β-cells exposed to gluco- and/or lipotoxic conditions and those in islets from T2D donors. We assessed whether metformin could relieve the human β-cell stress induced by pro-inflammatory cytokines (which mediate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giusti, Laura, Tesi, Marta, Ciregia, Federica, Marselli, Lorella, Zallocco, Lorenzo, Suleiman, Mara, De Luca, Carmela, Del Guerra, Silvia, Zuccarini, Mariachiara, Trerotola, Marco, Eizirik, Decio L., Cnop, Miriam, Mazzoni, Maria R., Marchetti, Piero, Lucacchini, Antonio, Ronci, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368307/ https://www.ncbi.nlm.nih.gov/pubmed/35954309 http://dx.doi.org/10.3390/cells11152465

Ejemplares similares

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes
por: Bosi, Emanuele, et al.
Publicado: (2022)

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets
por: Ciregia, Federica, et al.
Publicado: (2017)

The Role of Beta Cell Recovery in Type 2 Diabetes Remission
por: Suleiman, Mara, et al.
Publicado: (2022)

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
por: Bosi, Emanuele, et al.
Publicado: (2020)

Correction to ‘Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes’
por: Bosi, Emanuele, et al.
Publicado: (2021)

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis
por: Tesi, Marta, et al.
Publicado: (2021)

Proteomic Profiling Reveals Specific Molecular Hallmarks of the Pig Claustrum
por: Pirone, Andrea, et al.
Publicado: (2023)

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
por: Marchetti, Piero, et al.
Publicado: (2018)

Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus
por: Zallocco, Lorenzo, et al.
Publicado: (2021)

Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
por: Marselli, Lorella, et al.
Publicado: (2021)

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies
por: Yi, Xiaoyan, et al.
Publicado: (2022)

Role of Prosaposin and Extracellular Sulfatase Sulf-1 Detection in Pleural Effusions as Diagnostic Biomarkers of Malignant Mesothelioma
por: Zallocco, Lorenzo, et al.
Publicado: (2022)

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
por: Eizirik, Décio L., et al.
Publicado: (2012)

Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
por: Coomans de Brachène, Alexandra, et al.
Publicado: (2021)

Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human β-Cells
por: Ferri, Gianmarco, et al.
Publicado: (2021)

Fostering improved human islet research: a European perspective
por: Marchetti, Piero, et al.
Publicado: (2019)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells
por: Moore, Fabrice, et al.
Publicado: (2012)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes
por: Marchetti, Piero, et al.
Publicado: (2017)

TIGER: The gene expression regulatory variation landscape of human pancreatic islets
por: Alonso, Lorena, et al.
Publicado: (2021)

Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes
por: Masini, Matilde, et al.
Publicado: (2021)

Metabolic response of Insulinoma 1E cells to glucose stimulation studied by fluorescence lifetime imaging
por: Ferri, Gianmarco, et al.
Publicado: (2020)

Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression
por: Beghelli, Daniela, et al.
Publicado: (2023)

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
por: Lytrivi, Maria, et al.
Publicado: (2020)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
por: Alvelos, Maria Inês, et al.
Publicado: (2021)

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
por: Volkmar, Michael, et al.
Publicado: (2012)

Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy)
por: Barbalace, Maria Cristina, et al.
Publicado: (2021)

A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress
por: Giusti, Laura, et al.
Publicado: (2018)

Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
por: Martino, Luisa, et al.
Publicado: (2012)

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
por: Cunha, Daniel A., et al.
Publicado: (2012)

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes
por: Bugliani, M., et al.
Publicado: (2019)

MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s
por: Sebastiani, Guido, et al.
Publicado: (2018)

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans
por: Igoillo-Esteve, Mariana, et al.
Publicado: (2013)

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
por: Colli, Maikel L., et al.
Publicado: (2018)

Automated Assessment of β-Cell Area and Density per Islet and Patient Using TMEM27 and BACE2 Immunofluorescence Staining in Human Pancreatic β-Cells
por: Rechsteiner, Markus P., et al.
Publicado: (2014)

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022)

Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients
por: Giusti, Laura, et al.
Publicado: (2016)

Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
por: Caruso, Vanni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0vndm7ds97da6uefbe18sl78mo