Simvastatin Inhibits Brucella abortus Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model

Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase and has been found to have protective effects against several bacterial infections. In this study, we investigate the effects of simvastatin treatment on RAW 264.7 macrophage cells and ICR mice against Brucella (B.) abortus infe...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Trang Thi, Kim, Heejin, Huy, Tran Xuan Ngoc, Min, Wongi, Lee, Hujang, Reyes, Alisha Wehdnesday Bernardo, Lee, Johnhwa, Kim, Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368445/
https://www.ncbi.nlm.nih.gov/pubmed/35955474
http://dx.doi.org/10.3390/ijms23158337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368445/
https://www.ncbi.nlm.nih.gov/pubmed/35955474
http://dx.doi.org/10.3390/ijms23158337

Ejemplares similares