Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones

[Image: see text] The Ir-catalyzed C–H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fl...

Descripción completa

Detalles Bibliográficos
Autores principales: Hickey, Aobha, Merz, Julia, Al Mamari, Hamad H., Friedrich, Alexandra, Marder, Todd B., McGlacken, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368603/
https://www.ncbi.nlm.nih.gov/pubmed/35839386
http://dx.doi.org/10.1021/acs.joc.2c00973
_version_ 1784766188698468352
author Hickey, Aobha
Merz, Julia
Al Mamari, Hamad H.
Friedrich, Alexandra
Marder, Todd B.
McGlacken, Gerard P.
author_facet Hickey, Aobha
Merz, Julia
Al Mamari, Hamad H.
Friedrich, Alexandra
Marder, Todd B.
McGlacken, Gerard P.
author_sort Hickey, Aobha
collection PubMed
description [Image: see text] The Ir-catalyzed C–H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone—the core structure of many antibiotics.
format Online
Article
Text
id pubmed-9368603
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-93686032022-08-12 Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones Hickey, Aobha Merz, Julia Al Mamari, Hamad H. Friedrich, Alexandra Marder, Todd B. McGlacken, Gerard P. J Org Chem [Image: see text] The Ir-catalyzed C–H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone—the core structure of many antibiotics. American Chemical Society 2022-07-15 2022-08-05 /pmc/articles/PMC9368603/ /pubmed/35839386 http://dx.doi.org/10.1021/acs.joc.2c00973 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hickey, Aobha
Merz, Julia
Al Mamari, Hamad H.
Friedrich, Alexandra
Marder, Todd B.
McGlacken, Gerard P.
Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title_full Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title_fullStr Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title_full_unstemmed Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title_short Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones
title_sort iridium-catalyzed borylation of 6-fluoroquinolines: access to 6-fluoroquinolones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368603/
https://www.ncbi.nlm.nih.gov/pubmed/35839386
http://dx.doi.org/10.1021/acs.joc.2c00973
work_keys_str_mv AT hickeyaobha iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones
AT merzjulia iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones
AT almamarihamadh iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones
AT friedrichalexandra iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones
AT mardertoddb iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones
AT mcglackengerardp iridiumcatalyzedborylationof6fluoroquinolinesaccessto6fluoroquinolones

Ejemplares similares