Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage

Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant pathway and energy metabolism. We previously found that renal Sirt3 expression and activity were reduced in mice with type 2 diabetic nephropathy associated with oxidative stress and mitochondrial abnormalities...

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Detalles Bibliográficos
Autores principales: Locatelli, Monica, Macconi, Daniela, Corna, Daniela, Cerullo, Domenico, Rottoli, Daniela, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368634/
https://www.ncbi.nlm.nih.gov/pubmed/35955472
http://dx.doi.org/10.3390/ijms23158345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368634/
https://www.ncbi.nlm.nih.gov/pubmed/35955472
http://dx.doi.org/10.3390/ijms23158345

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