Cargando…

Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage

Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant pathway and energy metabolism. We previously found that renal Sirt3 expression and activity were reduced in mice with type 2 diabetic nephropathy associated with oxidative stress and mitochondrial abnormalities...

Descripción completa

Detalles Bibliográficos
Autores principales:	Locatelli, Monica, Macconi, Daniela, Corna, Daniela, Cerullo, Domenico, Rottoli, Daniela, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368634/ https://www.ncbi.nlm.nih.gov/pubmed/35955472 http://dx.doi.org/10.3390/ijms23158345

Ejemplares similares

Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection
por: Locatelli, Monica, et al.
Publicado: (2023)

Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis
por: Cerullo, Domenico, et al.
Publicado: (2022)

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
por: Locatelli, Monica, et al.
Publicado: (2020)

Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation
por: Pezzotta, Anna, et al.
Publicado: (2022)

Renal Expression of FGF23 in Progressive Renal Disease of Diabetes and the Effect of Ace Inhibitor
por: Zanchi, Cristina, et al.
Publicado: (2013)

MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy
por: Zanchi, Cristina, et al.
Publicado: (2017)

Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease
por: Rota, Cinzia, et al.
Publicado: (2018)

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome
por: Buelli, Simona, et al.
Publicado: (2022)

Sirt3 deficiency promotes endothelial dysfunction and aggravates renal injury
por: Pezzotta, Anna, et al.
Publicado: (2023)

Key fibrogenic mediators: old players. Renin–angiotensin system
por: Macconi, Daniela, et al.
Publicado: (2014)

Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II
por: Macconi, Daniela, et al.
Publicado: (2015)

Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets
por: Zoja, Carlamaria, et al.
Publicado: (2020)

A previously unrecognized role of C3a in proteinuric progressive nephropathy
por: Morigi, Marina, et al.
Publicado: (2016)

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling
por: Perico, Luca, et al.
Publicado: (2023)

Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs
por: Lavecchia, Angelo M., et al.
Publicado: (2023)

Protective Effects of Human Nonrenal and Renal Stromal Cells and Their Conditioned Media in a Rat Model of Chronic Kidney Disease
por: Imberti, Barbara, et al.
Publicado: (2020)

Renal Primordia Activate Kidney Regenerative Events in a Rat Model of Progressive Renal Disease
por: Imberti, Barbara, et al.
Publicado: (2015)

Sirtuin 3 in acute kidney injury
por: Perico, Luca, et al.
Publicado: (2015)

Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis
por: Perico, Luca, et al.
Publicado: (2021)

Mitochondrial-dependent Autoimmunity in Membranous Nephropathy of IgG4-related Disease
por: Buelli, Simona, et al.
Publicado: (2015)

Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function
por: Perico, Luca, et al.
Publicado: (2017)

Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice
por: Casiraghi, Federica, et al.
Publicado: (2021)

Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome
por: Buelli, Simona, et al.
Publicado: (2019)

Angiotensin II revisited: new roles in inflammation, immunology and aging
por: Benigni, Ariela, et al.
Publicado: (2010)

The case of complement activation in COVID-19 multiorgan impact
por: Noris, Marina, et al.
Publicado: (2020)

SARS-CoV-2 and the spike protein in endotheliopathy
por: Perico, Luca, et al.
Publicado: (2023)

Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
por: Guida, Maria Clara, et al.
Publicado: (2019)

Fetuin‐A aggravates lipotoxicity in podocytes via interleukin‐1 signaling
por: Orellana, Jana M., et al.
Publicado: (2017)

Dehydrozingerone inhibits renal lipotoxicity in high‐fat diet–induced obese mice
por: Lee, Eun Soo, et al.
Publicado: (2021)

Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury
por: Zhang, Qinghai, et al.
Publicado: (2018)

Imaging the Kidney with an Unconventional Scanning Electron Microscopy Technique: Analysis of the Subpodocyte Space in Diabetic Mice
por: Conti, Sara, et al.
Publicado: (2022)

Evaluation of the Zucker Diabetic Fatty (ZDF) Rat as a Model for Human Disease Based on Urinary Peptidomic Profiles
por: Siwy, Justyna, et al.
Publicado: (2012)

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture
por: Zoja, C., et al.
Publicado: (1993)

TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced lipotoxicity in the kidney
por: Nakamura, Jun, et al.
Publicado: (2023)

Correction to: Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury
por: Zhang, Qinghai, et al.
Publicado: (2022)

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice
por: Zhang, Yang, et al.
Publicado: (2023)

Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet
por: Ishikawa, Shingo, et al.
Publicado: (2013)

Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity
por: Kim, Yaeni, et al.
Publicado: (2019)

Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice
por: George, Jasmine, et al.
Publicado: (2021)

Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity
por: Jiang, Jin-Jin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rgv6bf28vumdebdvuhhu9161op