Dysregulation of SIRT3 SUMOylation Confers AML Chemoresistance via Controlling HES1-Dependent Fatty Acid Oxidation

Sirtuin 3 (SIRT3) deacetylase is a key regulator for chemoresistance in acute myeloid leukemia (AML) cells due to its capability of modulating mitochondrial metabolism and reactive oxygen species (ROS). SIRT3 is de-SUMOylated by SUMO-specific peptidase 1 (SENP1), which enhances its deacetylase activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yirong, Shen, Yajie, Wei, Weiqing, Wang, Wenhan, Jiang, Daiji, Ren, Yizhuo, Peng, Zijing, Fan, Qiuju, Cheng, Jinke, Ma, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368767/
https://www.ncbi.nlm.nih.gov/pubmed/35955415
http://dx.doi.org/10.3390/ijms23158282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368767/
https://www.ncbi.nlm.nih.gov/pubmed/35955415
http://dx.doi.org/10.3390/ijms23158282

Ejemplares similares